Even infinity gloves are not the strongest weapon on this list.
Normally, the most powerful weapons in Marvel’s universe have a cosmic origin – such as the six infinity stones Thanos used on his gloves. However, not only are these stones derived from the “quintessence of stars” – there are also similar antiques of infinite potential that need “attendance”. Therefore, the following is a list of the ten strongest cosmic artifacts in the Marvel comics.
10. Mandarin’s Rings

Starting the list are the rings of Mandarin villains. Found in the Valley of the Spirits in China, the ten rings are actually the source of energy found on a destroyed ship from Maklu-IV, a planet with massive dragons-like creatures that have name Makluans.
Each ring has its own power, from releasing ice energy, electricity to vortex beams or the ability to rearrange matter. Mandarin connected these rings to his mind, making him the only one capable of using them.
9. Watcher’s Eyes

A cosmic artifact used to be part of the Uatu cosmic entity, otherwise known as the Watcher. This creature reigns on the moon and is responsible for watching and preserving the history of everything in Marvel. In the Original Sin story, Uatu is found by heroes in a state of … death.
Later, the heroes discovered that the person who killed Uatu was none other than … Nick Fury, in order to use the eye as a way to detect threats from extraterrestrials.
8. Ultimate Nullifier – ultimate destructive weapon

One of the strongest weapons in the Marvel universe is the Ultimate Nullifier. First seen in the battle between Fantastic Four and Galactus, this device is stolen by Human Torch and Uatu from Galactus’s ship. Reed Richards has threatened to use it, and this keeps Galactus away from Earth.
Not only can this device destroy any target the user wishes, but in the hands of an almighty entity, it can also completely destroy the timeline from the multiverse.
7. Cosmic Cube

More known thanks to Captain America and the Avengers in the Marvel movie universe, but this cube has many different versions in the comics. These artifacts are used to store the changing reality from the universe of the Beyonders.
Cosmic Cube appeared most recently in the Secret Empire event. Fragment of this cube’s mind, Kobik, was tricked into creating a Captain America to serve Hydra until Steve Rodgers convinced Kobik to correct reality.
6. Quantum rings

This all-powerful weapon created by Eon bestowed on the Protector of the Universe. The most known person to use this weapon is Quasar.
These bracelets allow users to draw energy from the Quantum Zone, a place where all the energy in Marvel comes from. They can control the electromagnetic spectrum, open the worm holes to move through space, detect energy or even protect the wearer from enemy attacks with an energy shield.
5. Phoenix Blade

A powerful sword, the Phoenix Blade is used by the second recipient of the Phoenix Force – Rook’shir – to destroy the Shi’ar empire.
After the Phoenix Force left Rook’shir, a portion of its energy was integrated into the weapon. The Korvus descendant used the sword to destroy Rachel Gray, but it was the energy within it that connected the minds of the two – and shared painful memories between Rachel and Korvus.
4. Galactus’ Ship

The ship of the Galactus world destroyer is known as Taa II or Worldship. It was created when Galatus woke from a hibernation after the Big Bang.
After destroying the first world, he used the planet’s raw materials to create the ship as respect for his planet Taa. Not only are there many weapons kept on this ship (including the Ultimate Nullifier), Galatus also captures a lot of other alien creatures.
3. Infinity Gems – 6 Infinity Stones

Perhaps the most famous cosmic weapon after appearing in recent Marvel series, the Infinity Gems consists of six power stones that give users different powers.
These six stones include Soul, Time, Space, Mind, Reality and Power. Taken together, these stones are capable of changing the reality of the Marvel universe. Perhaps its most notorious use case is when attached to another cosmic weapon, which is …
2. Infinity gloves

Infinity glove. It was created as a place to converge the power of all six infinity stones. Thanos obtained this artifact after stealing all six stones from the Elders of the Universe in order to show his love to the grim reaper.
With just a snap of his finger, Thanos wiped out half of all living things in the entire universe – but not enough to impress Death, and the plan was broken. Later, it was also used a few times in Infinity Saga.
1. The Heart Of The Universe – The Cosmic Mind

Described by Thanos as an antiquity so strong that the gloves are as polar as an ant, The Heart of the Universe is considered the most powerful object in the Marvel comics. This is the result of Supreme Being in order to balance good and evil – it can control the entire world itself.
Thanos when holding this artifact is considered to be the strongest creature after The One Above All, with abilities such as reviving the dead, changing reality, etc.
According to CBR